UniProt Release 2022_04 The UniProt consortium European Bioinformatics Institute (EBI), SIB Swiss Institute of Bioinformatics and Protein Information Resource (PIR), is pleased to announce UniProt Knowledgebase (UniProtKB) Release 2022_04 (12-Oct-2022). UniProt (Universal Protein Resource) is a comprehensive catalog of information on proteins. UniProtKB Release 2022_04 consists of 230,496,503 entries (UniProtKB/Swiss-Prot: 568,363 entries and UniProtKB/TrEMBL: 229,928,140 entries) UniRef100 Release 2022_04 consists of 318,161,042 entries UniRef90 Release 2022_04 consists of 152,318,239 entries UniRef50 Release 2022_04 consists of 54,143,378 entries UniParc Release 2022_04 consists of 528,142,835 entries UniProt databases can be accessed from the web at http://www.uniprot.org and downloaded from http://www.uniprot.org/downloads. Detailed release statistics for TrEMBL and Swiss-Prot sections of the UniProt Knowledgebase can be viewed at http://www.ebi.ac.uk/uniprot/TrEMBLstats/ and http://web.expasy.org/docs/relnotes/relstat.html respectively.